Division of Infectious Diseases

Ambulatory Stewardship: A Little Bit of Everything Goes a Long Way

Inappropriate outpatient antibiotic use remains a problem needing to be addressed as part of the strategy to reduce antimicrobial resistance. Jasmine Marcelin, MD and Phil Chung, PharmD led a multifaceted approach to reducing antibiotic use in ambulatory clinics within our Nebraska Medicine hospital system, recently published in Infection Control and Hospital Epidemiology.

SHEA Journal Club Review: “Not Throwin’ Away My Shot”: Early data for COVID-19 vaccination in previously infected healthcare workers and solid organ transplant recipients

As more vaccinations are completed worldwide, specific vaccine strategies and outcomes among special patient populations are newly available. Two populations of interest include vaccinees with previous COVID-19 and those with a history of a solid organ transplant. Dr. Erica Stohs reviews early data for SHEA Journal Club

Ongoing Debate on the Treatment of Staphylococcus aureus Bacteremia

Dr. Andre Kalil, our Director of Transplant Infectious Diseases, recently co-authored a reply to Geriak et al.: “Clinical Data on Daptomycin plus Ceftaroline versus Standard of Care Monotherapy in the Treatment of Methicillin-Resistant Staphylococcus aureus Bacteremia.” Debate around the findings of this article was recently featured by Dr. Razan El Ramahi in the IDSA ID journal club and on this blog. In their reply to… Continue Reading

Contraception and Antiretroviral Therapy: Important Interactions to Keep in Mind

Dr. Kimberly Scarsi recently published an important study in Lancet HIV: “Antiretroviral therapy and vaginally administered contraceptive hormones: a three-arm, pharmacokinetic study.”  We were excited to learn more about and feature her work! Could you please give us a brief summary of the study you performed? This was a pharmacokinetic evaluation of the effect of antiretroviral therapy (ART) on vaginally administered hormones. Overall, 84 women… Continue Reading

Journal Club: Should vancomycin be given as prophylaxis for Clostridioides difficile infections?

The following is a review by one of our fellows, Dr. Randy McCreery, who at a recent journal club presented a paper by Johnson, et al.: Effectiveness of Oral Vancomycin for Prevention of Healthcare Facility-Onset Clostridioides difficile Infection in Targeted Patients During Systemic Antibiotic Exposure, Clinical Infectious Diseases, 28 September 2019. In addition, Drs. McCreery, Cawcutt, Cortes-Penfield & Van Schooneveld published a letter to the editor… Continue Reading

Blood culture contamination–it’s a big deal

Blood cultures are a key diagnostic test to detect bacteremia and appropriately treat patients with sepsis and are performed approximately 30 million times in the United States yearly. Unfortunately, contamination of blood cultures occurs in the 0.5% to 5% of samples (approximately 25% of positive blood cultures are due to contamination) which leads to inappropriate antibiotic treatment, additional unneeded tests, extended hospital length of stay,… Continue Reading

PharmToExamTable: What do we know about Etravirine for HIV?

Recently, several of our HIV pharmacist colleagues in our Division of Infectious Diseases at UNMC/Nebraska Medicine, published an invited review in Clinical Pharmacokinetics entitled: Clinical Pharmacokinetics and Pharmacodynamics of Etravirine: An Updated Review.  The first author, Dr. Josh Havens PharmD, wrote this summary describing the review article. What prompted the review? This was an invited review, but there was only one previously completed shortly after… Continue Reading

Unpacking the new IDSA Community-Acquired Pneumonia guidelines

We are always excited to have our ID fellows provide guest blog posts. Second year ID fellow Dr. Lindsey Rearigh (follow her on Twitter @LRearigh) was recently on her Antimicrobial Stewardship rotation and reviewed the latest published guidelines for Community-Acquired Pneumonia (CAP).  The American Thoracic Society (ATS) and Infectious Diseases Society of America (IDSA) recently released updated community-acquired pneumonia (CAP) guidelines. The first immediate implication… Continue Reading

Journal Club – Stewardship in Community Hospitals: How should we spend our limited resources? 

Stewardship in Community Hospitals: How should we spend our limited resources?  The following is a review by our ID Fellowship Program Director Dr. Trevor Van Schooneveld from our last Infection Control/Antimicrobial Stewardship Journal Club. He discussed the article by Anderson et al: Feasibility of Core Antimicrobial Stewardship Interventions in Community Hospitals. JAMA Network Open.  2019;2(8):e199369.   Antimicrobial stewardship is important to improving patient care and outcomes and numerous entities… Continue Reading

Treatment of Osteomyelitis – What’s the Evidence for our Strategies?

New UNMC ID publication alert! #ReadUNMCID Recently, the newest member of our Division of Infectious Diseases at UNMC/Nebraska Medicine, Dr. Nicolas Cortes-Penfield published an invited review in Open Forum Infectious Diseases entitled: The History of Antibiotic Treatment of Osteomyelitis.  Dr. Cortes-Penfield wrote this summary describing the review article, which was commissioned after he published a comprehensive blog post (on his blog IDJournalClub.com) about the history… Continue Reading