Division of Infectious Diseases

Nebraska Medicine to Host Emerging Infectious Disease Preparedness Workshop March 27-28

 

Nebraska Medicine has been home to one of the few Biocontainment Units in the country, and was one of three selected to care for citizens affected by the Ebola outbreak. Dr. Angela Hewlett, one of our own UNMC Infectious Disease Physicians, is the Medical Director of the Nebraska Biocontainment Unit (NBU)  and Associate Medical Director of Infection Control & Epidemiology at Nebraska Medicine.

Our NBU is one of several training sites for Emerging Infectious Disease Preparedness training, and Dr. Hewlett shared an upcoming training event with us.

“The National Ebola Training and Education Center (NETEC) is a collaborative effort between UNMC, Emory Medicine, and NYC Health Hospitals Bellevue in New York City; in that effort we host training courses here on [UNMC] campus, we attend training courses on the campuses of our collaborators and we also visit a variety of medical facilities to enhance preparedness for highly infectious diseases. We will be hosting a course on campus here at UNMC on March 27 and 28, where we will have over 130 attendees from multiple disciplines, from all over the United States to come and learn about preparedness efforts.”

The workshop target audience includes healthcare workers and public health professionals. The workshop will be free of charge, but will provide continuing education credits. Course offerings include Pathogens of concern, Emergency Management, Laboratory and Clinical Lab Skills, Leadership Strategies, and EMS/Pre-Hospital Operations, with additional skills stations utilizing their own personal protective equipment and protocols.

For more information about the NETEC education and training offerings, click here.

Josh Havens, PharmD on “Why I Love ID”

Why I Love ID: 

Infectious diseases, in general, is quite interesting, but I can really only speak from an HIV perspective. My initial career interests were not in infectious diseases and it was not until I threw myself into this niche world of HIV that I started to recognize a true affinity toward the field.  It is rare to find an infection that is such long-lived and durable despite enormous efforts to cure it.  I find the complexity and evasive nature of the HIV virus is fascinating.  I love the challenge that the treatment of HIV can often provide.  In most cases, the majority of your patients create a small portion of your work/effort yet it’s that 10% that can often require 95% of your time.  I love the 10% because of the upside.  The challenges to get these patients better are multifaceted and generally difficult, but the smallest changes in their medical care can result in noticeable positive changes.  There are many other reasons I love this field but the struggles it can present are sometimes what I enjoy the most.  

Josh Havens, PharmD

Learn more about the UNMC ID Division here.


 

World Social Work Day – Meet our HIV Case Management Team

The official theme for Social Work Month in March 2018 is “Social Workers: Leaders. Advocates. Champions.”

Social workers are the glue that keeps clinical practices together as we balance the need to care for patients with the socioeconomic needs of the individual patients.

At the Specialty Care Center, our Case Management team works tirelessly to ensure that patients’ needs are met; they enroll patients in insurance, review Ryan White eligibility, and provide gift cards/coupons for extra monetary support. They are a valuable resource to the clinicians, providing insight into patients’ current living situations, relationship struggles, or drug abuse, all of which can affect adherence and treatment effectiveness.

Meet our Case Management Team:

Tacy Slater, MSW, MPH joined the HIV team in July of 1999 after being employed as a case manager with the Nebraska AIDS Project for five years.  She received her Master’s degree in Social Work and Public administration from the University of Nebraska at Omaha.  Tacy is a clinic social worker, patient services coordinator and the coordinator for the Ryan White Parts C and D Programs.  She is strongly committed to quality care and access for our patients and always goes the extra-mile for patients.

Jeremy Johnson, MSW joined the HIV team in October 2005 as a social worker and coordinator for the Nebraska AIDS Drug Assistance Program (ADAP). He received his Master’s degree in Social Work from the University of Denver, Colorado. Prior to working with us, he was the Southwest Iowa case manager for Nebraska AIDS Project. He is committed to working with this population of clients and greatly enjoys being a part of the team.

Renae Furl, MPH joined the HIV team in August 2007 after being employed as a case manager with the Nebraska AIDS Project for nearly five years. She received her Master’s degree in Public Health from the University of Nebraska Medical Center.  Renae is committed to helping patients find ways to pay for their care and medications, and coordinates the insurance program through Nebraska ADAP.  Her position is titled “Healthcare Access Coordinator”.

Laura Krajewski, MPA joined the HIV team in 2013 as the Patient Outreach Specialist.  Behind the scenes, Laura coordinates quality assurance efforts for the Ryan White Parts C and D Programs.  A Nebraska native, Laura returned to Omaha after working at an AIDS Service Organization in Massachusetts for eight years. She received her master’s degree from Clark University and also served in the Peace Corps in Kazakhstan teaching English to high school students. She is interested in the social impact HIV/AIDS has on individuals living with the disease.

Samantha L. Jones, BSW joined the HIV team in May 2016.  She received her BSW from the University of Iowa and was employed with Goodwill for over five years. Most recently she was the Intake Coordinator under the Federal Workforce Innovation and Opportunity Act (WIOA), working to provide outreach and access to employment and training opportunities in order to assist individuals in becoming self-sufficient. Samantha works with the AIDS Drug Assistance Program (ADAP) participants to access and maintain insurance coverage through the Affordable Care Act, help navigate insurance plans, and increase insurance literacy among recipients.  Behind the scenes, Samantha coordinates quality assurance efforts for processing pharmaceutical claims, medical co-pays, and tax reconciliation efforts, while ensuring ADAP meets program requirements.

L-R: Samantha L. Jones BSW , Renae Furl MPH, Jeremy Johnson MSW, Tacy Slater MSW, MPH, Laura Krajewski MPA

Many clinics are not as fortunate as we are to have social workers integrated into the team, let alone a whole group of social workers. Together, they are a force to be reckoned with, and UNMC ID is grateful for their dedication to their craft and to our patients.

Learn more about UNMC HIV care at the Specialty Care Clinic here.

ID Journal Club Presents… Molecular Rapid Diagnostic Tests Improve Clinical Outcome

Bloodstream infections are associated with high mortality.  Blood cultures are a reliable and accurate method for the identification of bloodstream infections but can take up to 5 days or even more being finalized, leading to delays in initiation of effective antibiotic therapy. The Infectious Disease Society of America (IDSA) recommends the use of rapid diagnostic testing with support of antimicrobial stewardship for better clinical outcomes, and President Obama include development of rapid diagnostic tests as one of the five overarching goals of the “National Action Plan for Combating Antibiotic Resistant Bacteria”.

Rapid diagnostic tests in bloodstream infections were discussed at a recent UNMC infectious disease journal club. “The effects of Molecular Rapid Diagnostic Testing on clinical outcomes in Bloodstream Infections systemic review and meta-analysis” published in Clinical Infectious Disease in Jan 2017 was presented by infectious disease fellow Dr. Rajendra Karnatak, with enthusiastic discussion among the group.

Recent advances in rapid diagnostic tests like PCR, Matrix-assisted Laser Desorption/Ionization Time of Flight (MALDI-TOF) Mass Spectrometry, and PNA-FISH have significantly reduced time to identification of microorganisms in bloodstream infections. The effect of molecular rapid diagnostic tests on important clinical outcomes like mortality, time to effective therapy, length of stay, and reduction of treatment cost has not been well established.

The article Dr. Karnatak reviewed studied the effects of utility of molecular rapid diagnostic tests on mortality, time to effective therapy, and length of stay (LOS). 31 studies met inclusion criteria for systemic review/meta-analysis and 5920 bloodstream infections were studied. All included studies compared conventional microbiological methods to molecular rapid diagnostic tests.  Results indicated molecular rapid diagnostics would need to be used 20 times to prevent 1 death within 30-day period, and a statistically significant overall reduction in mortality with use of rapid diagnostics in combination with antimicrobial stewardship (ASP).  There was a mean difference of -5.03 hours in time to effective therapy in the molecular rapid diagnostic tests group as compared to conventional microbiological methods. Time to effective therapy was most pronounced in bloodstream infections due to Enterococcus spp.  The rapid diagnostic test group demonstrated a shorter LOS by 2.48 days compared to conventional microbiologic methods.

The included enterococcal bloodstream infection study contributed to some heterogeneity of the meta-analysis, with respect time-to-effective therapy.  When the enterococcal bloodstream infection study was excluded from analysis, there was only 1.89 hours mean difference in time-to-effective therapy.  Without the support of antimicrobial stewardship, results favored mortality benefit with the use of molecular rapid diagnostic tests but failed to demonstrate statistical significance. These findings further support 2016 IDSA recommendations for use of rapid diagnostic tests with support of ASP for better clinical outcome.

Use of rapid diagnostic tests is one step in a multi-step process that includes appropriate ASP structure, appropriate laboratory notification process, timely intervention and availability of resources for ASP. The majority of studies included in this meta-analysis did not have 24/7 support of ASP.  Although this study clearly demonstrated benefit in reduction of LOS, it did not mention overall cost benefit. Molecular rapid diagnostic tests can revolutionize patient care, allowing for initiation of appropriate tailored therapy earlier during the treatment of critically ill patients. ASP and molecular rapid diagnostic tests together can have significant impact on fight against increasing antimicrobial resistance.

M4 Students in our HIV Enhanced Education Track present Capstone Projects…and Today is MATCH DAY!

The UNMC College of Medicine offers a unique Enhanced Medical Education Track (EMET) program which provides an opportunity for medical students to delve into particular disciplines of interest in the field of medicine throughout their four year degree program. Track students attend seminars, preceptorships and complete a research project culminating in a poster or conference presentation.

Yesterday, on the eve of their Match Day, our two M4 Students, Rebecca Osborn and Daniel Cloonan (under the mentorship of Dr. Sara Bares) presented their Capstone Projects at UNMC College of Medicine.

Today, after years of hard work, months of interviews, weeks of decision and the most anxiety-filled week of their lives, they found out where they will be spending the next few years of their lives as newly minted doctors.

Rebecca’s project focused on a collaborative care program to help with medication adherence in patients living with HIV.  This collaborative worked with a local community pharmacy to create a program of direct engagement between pharmacists and patients in order to improve adherence. She will be submitting her work for presentation at a national conference and for publication. Rebecca will be continuing her medical training with Internal Medicine Residency at Yale. We wish her all the best and hope to see her again in the future for ID fellowship!

Daniel’s project looked at the gender affirming hormone therapy taken by transgender patients and possible interactions with Pre-exposure prophylaxis (PrEP), which is recommended to help prevent HIV infection in persons at high risk for acquiring the disease. Because of a fear of drug-drug interactions, many transgender individuals may avoid PrEP when they are at high risk, fearing an interruption in their hormone therapy. Daniel’s study is part of a larger study being led by Kim Scarsi, PharmD (HIV Clinical Pharmacist at the Specialty Care Center and Associate Professor in the College of Pharmacy) and Lauren Cirinccione, PharmD (Pharmacy Practice Fellow). The project, collaborating with the UNMC College of Pharmacy, hopes to answer this question and by doing so, remove some barriers to PrEP engagement when needed. Daniel will be continuing his medical training with a General Surgery Residency at Beth Israel Deaconess Medical Center. We wish him all the best in the future!

Each year, our UNMC HIV clinic takes two medical students into the EMET track, and we look forward to working with them over the course of their undergraduate medical training to immerse them in HIV care and Infectious Diseases. We will soon be announcing our new M1 EMET students, who will start working with us over the coming summer.

Congratulations again to Becky and Daniel, we are proud of you! And congratulations to all M4s out there who found out where they matched today!

More information about the EMET program can be found here.


 

What Patient Safety Means to Us – Part 2

In endeavoring to give you a real flavor of how important patient safety is to all of us, we have more comments today from our team. Patient safety is important to all of us and we wish we could highlight the all of important work everyone in our Division is doing to provide the best possible care while still preventing harm.

 

Adrienne Sy, RN, BSN; Quality Lead for CLABSI & CAUTI reduction starts us off today:

Patient safety means protecting someone’s loved one from harm.  My grandmother passed away after a fall two weeks before I took the NCLEX, and my mother-in-law passed away after a bloodstream infection three months after I got to marry her eldest son.

Two things that I am very excited to help run/coordinate are the CAUTI and CLABSI Roundups.  It gives me a chance to work with the nursing units, and I believe that these have been very helpful in identifying what is done well and what our areas of opportunity are.

 

Michelle Schwedhelm, RN adds a great global view of safety at Nebraska Medicine/UNMC:

Patient Safety is creating a safe zone and processes for patients seeking care at Nebraska Medicine. 

One project is doing Fire and Severe Weather Drills with our staff to assure they know how to evacuate and how to mitigate danger for our patients.  Another is our new Daily Shout Out meeting where we identify safety issues for patients and staff and encourage prompt resolution.  Visibility is at the highest levels of the organization.

 

Dr. Kelly Cawcutt on preventing harm in the ICU:

Dr. Kelly Cawcutt, Associate Director of Infection Control and Epidemiology

Patient safety is about always providing the best patient-centered care while preventing harm, for all patients. I work in the ICU also, and there we are providing care to the sickest patients in the hospital and often have to use invasive procedures and devices for life support measures. Providing excellent clinical care is one component of patient safety, but through working in Infection Control, I can also focus on preventing harm are a larger scale from how we prevent the spread of infections in the hospital to which types of devices we use in the ICU. 

Some examples of projects I have worked on are developing a vascular access algorithm to ensure we use the right device at the right time for our patients – whether that is a peripheral IV, midline, central venous catheter or another type of device. I also am working on how to address and prevent ventilator-associated events, including pneumonia, for our patients who require mechanical ventilation in the ICU. These projects reduce harm, prevent adverse events and in the end, I believe this work helps save lives. 

 

To me, patient safety is about imagining yourself as each patient or family member being cared for in the hospital, and asking “is the care I’m delivering what I would want for myself or my family?”, and if the answer to that is “no”, personally seeking ways to improve that care for our patients. 

Dr. Jasmine Riviere Marcelin is the Associate Medical Director, Nebraska Medicine Antimicrobial Stewardship Program

Much of my work in Antimicrobial Stewardship is focused on reduction of antibiotic use, primarily with a patient safety mission. Antibiotics are the only drugs where an individual prescriber’s use can affect patients s/he never even cared for. For example, when patients are prescribed antibiotics for viral illnesses which do not require them, this may lead to development of bacteria resistant to antibiotics. When a patient in that community then develops a serious bacterial infection with this resistant organism, they may face grave complications from the actual bacteria or from use of alternative antibiotics with serious adverse effects or toxicities. Collaborating with the Nebraska Antimicrobial Stewardship Assessment and Promotion Program (ASAP) and Nebraska Health Network (NHN), I created several educational materials for outpatient prescribers on appropriate use of antibiotics in upper respiratory illnesses.

Additionally, skin/soft tissue infections are another area where antibiotics are overused, and I personally have seen patients develop kidney failure from combination treatment with vancomycin and piperacillin-tazobactam for cellulitis when only cefazolin was indicated. I am currently working on updating our institutional skin/soft tissue infection guidance document which will help antibiotic prescribers make the right treatment choices for specific skin/soft tissue infections. These are just two of the many projects our Antimicrobial Stewardship Team are working on to decrease antibiotic overuse and misuse, keeping patients safe by reducing adverse effects, drug toxicities and antibiotic resistance. 


 

Antimicrobial Stewardship Program Takes Patient Safety Personally

At Nebraska Medicine, our Antimicrobial Stewardship Program’s (ASP) clinical mission is to optimize the utilization of antimicrobial agents, thereby improving patient outcomes (by reducing the risk of adverse events and Clostridium difficile infection) and limiting the spread of antimicrobial resistance.   These Antimicrobial Stewardship activities have been mandated by the Joint Commission and our program has been expanding its reach to include our satellite hospitals and our outpatient clinics to achieve this mission. Since a large majority of inappropriate antibiotic use occurs outside of the hospital, our outpatient initiatives are currently focused on education of clinic providers and patients on not using antibiotics for conditions that do not require them.

On the inpatient side, our stewardship activities have many impacts on patient safety.  First, many studies have demonstrated the benefit of early Infectious Disease consultation for patients with Staphylococcus aureus bloodstream infection (SAB). When ID doctors are involved, patients are less likely to die or suffer complications, respond faster to therapy and will have fewer adverse effects.  At Nebraska Medicine, we review approximately 150 SAB cases per year to prompt ID consultation. In addition, the discussion between the ASP reviewer and the primary team ensures the appropriate antibiotic is started immediately, even in advance of the ID consultation.

Last year, our ASP program documented over 2500 reviews of patients for appropriate antibiotic use, with 381 interventions to reduce antibiotic use by either discontinuing or de-escalating therapy, with a 90% acceptance rate of interventions. Not only did we assist with narrowing antibiotic use, 97 patients with untreated or resistant infections were identified and subsequently initiated on therapy as a result of ASP review, and nearly 200 ID consult requests were implemented in highly complex cases.

Furthermore, our ASP interventions have also resulted in reductions of vancomycin and piperacillin/tazobactam combination therapy when unnecessary. The combination of these two antibiotics has been shown to increase risk of kidney failure (which leads to worse clinical outcomes for patients), and the simple act of switching to alternative antibiotics to avoid this risk has tangible patient safety benefits.

In 2016, new initiatives were introduced to improve timing and redosing of antibiotic prophylaxis for surgery, in an effort to reduce the risk for surgical site infections (SSI). Coupled with the new SSI prophylaxis guidance, the program developed guidance on how to manage patients with beta-lactam allergies.  This is important for patient safety because many patients receive 2nd or 3rd line antibiotics inappropriately in the context of remote penicillin allergies. Sometimes, like in the case of surgical prophylaxis, the data is clear that use of antibiotics other than cefazolin can lead to increased SSI risk. Providing evidence-based guidance in collaboration with our allergists empowers physicians to provide best care for their patients without perceived harm of allergic reactions.

Antimicrobial stewardship is the balance between treating patients effectively and keeping them safe from harm.

Here at Nebraska Medicine, we take that balance personally; practicing Serious Medicine, delivering Extraordinary Care.


 

What Patient Safety Means To Us – Part 1

As mentioned on Monday, patient safety is a primary focus of our work, particularly in Infection Control and Epidemiology. To really highlight the commitment to this initiative, we wanted to share a series on what patient safety means to us and a few examples of how we have implemented that into our work.

 

Per Dr. Mark Rupp,  Division Chief and Medical Director of Infection Control & Epidemiology:

Patient safety, is the very reasonable expectation from our patients, that although in healthcare we do things that are inherently dangerous, we minimize the risk of harm as much as is possible.  Quite simply, we eliminate preventable harm.

In the Infection Control and Epidemiology Department our whole effort is dedicated toward minimizing the occurrence of healthcare associated infections (HAIs). 

In recent years at Nebraska Medicine we have taken aggressive measures to decrease central line associated bloodstream infections (CLABSI) and catheter-associated urinary tract infections (CAUTI).  We emphasize horizontal interventions which are measures that impact all patients or broad groups of patients – examples of horizontal interventions are hand hygiene, chlorhexidine bathing, and environmental cleaning and disinfection.  At the present time we are in the middle of a campaign to decrease infection due to Clostridium difficile and launching programs to further limit infections following surgery (surgical site infections).  Much of the work we do is behind the scenes and includes making sure the air is safe, the water is free of pathogens, and systems to provide clean and sterilized instruments and devices are working properly.” 

 

Dr. Angela Hewlett, Medical Director of Clinical Operations for the Biocontainment Unit,  Associate Medical Director of Infection Control & Epidemiology and Director of Infectious Diseases Outpatient Clinic said:

To me, ‘patient safety’ is the practice of doing everything we can to prevent harm from coming to our patients.  Patient safety protocols should be based on the best available scientific evidence and always be accompanied by education (for healthcare workers as well as patients).

 Examples:

  1. After it was noted that patients with fractures were placed on a variety of antibiotic regimens in an effort to prevent infections, I worked on a collaborative project with the Department of Orthopaedic Surgery to standardize antibiotic recommendations for patients with fractures.  We created an Epic order set, and conducted educational sessions with multiple physician groups, including the Emergency Department, Trauma Surgery and Orthopedics.  This evidence-based protocol will help with patient safety by ensuring that patients are receiving appropriate antibiotics and dosing for an appropriate amount of time. 
  2.  Chlorhexidine (CHG) bathing is a modality that has been shown to decrease healthcare-associated infections, and is a standard practice for all inpatients at UNMC.  Dr. Andrea Green and I created a survey of nursing staff to determine what barriers exist in regards to CHG bathing of patients.   We used the information generated from the survey to create education on the benefits of CHG bathing in an effort to increase compliance with this practice. 

 

Kim Hayes, RN and Infection Preventionist added her perspective with:

What does patient safety mean to me?  First and foremost, we must not harm our patients during the course of their treatment, either in our cares or with our devices.  We must be mindful that our patients were not always as we see them and their families have the expectation that we will keep them safe and not let harm come to them while they stay with us.

Two projects that I have been involved with were the CAUTI reduction team during which every nurse/tech in the facility was instructed in catheter insertion and appropriate catheter cares, supply lines were standardized and we updated our devices(sterile piston irrigation set).  The second was moving from the outdated split septum IV infusion sets and connectors to meet the industry standard with the needleless sets and connectors.  This was an enterprise wide change that touched every department and made IV treatment safer.  Alligator clips no longer popped off and infused medications into the bed linens, needles were no longer used in the system, so nurses are safer today as a result.  

Learn more about ID and Infection Control at UNMC.

 

 


 

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Patient Safety Awareness Week

“4 in 10 Americans say they have experienced a medical error in their own care or in the care of a loved one.”

Preventable Harm is critical to reduce in healthcare. It is a major cause of death, disability and costs, therefore the Institute for Healthcare Improvement created an initiative of Patient Safety Awareness Week from March 11 to the 17th. The mission is to raise awareness among providers and patients alike, to recognize the paramount importance of patient safety and that no matter what, WE ARE ALL PATIENTS. We all want medical care that is both excellent and safe.

How can you get involved with the events this week?

Take the pledge to help reduce harm.

Join the webinar at 12pm Central time for Engaging Patients and Providers: Speaking Up for a Culture of Safety

Join the Twitter chat. #PSAW18 Friday March 18th from 11AM -12PM Central Time on  Building a Culture of safety.

Check out resources for your institution and other events here: http://www.unitedforpatientsafety.org/

Here in the realm of Infectious Diseases, much of our work surrounds efforts that directly impact, and improve, patient safety. From antibiotic stewardship aid in improving our drug choices while minimizing adverse events to choosing the right types of IV catheters to even what may seem mundane, like making sure hand washing is easy-to-do and DONE! Throughout this week, we will be posting thoughts on what patient safety means to us and projects we have worked on that focus on patient safety.  This will included a broader array of the invaluable team members helping us all work toward safer healthcare everyday.


 

Match Day – Congratulations and Best Wishes!

Today is the day in which “the MATCH” happens for our 2018 students. This morning, at 11 AM they will find out if they matched into a residency program and this Friday, March 16, they will find out where they matched. Match Day is a day full of anxiety, excitement and some trepidation as you find out if you need to move, what city and state you may be relocating to before entering years of medical training as a resident.

The Match is meant to remove pressure and bias from both students and institutions during the process of choosing a residency program, but it is laced with the unknown and lack of control of where you go, and what you do next. It is a unique right of passage for physicians as they launch into the years of training after earning their MD.

Congratulations to medical students at UNMC and across the country as you celebrate and take the next steps toward becoming the future of medicine. No matter the result, you have come this far and you will continue to step forward as a physician into a realm of extraordinary opportunity to witness, and care for humanity, with all of it’s vulnerability and complexity.

From the UNMC ID Division, we wish you all the best and of course, we hope to see you join us again as fellows!