Research Announcements

Microbiome Research Seminar

Inflammation and dysbiosis in periodontitis: Mechanisms and therapeutic intervention
George Hajishengallis, DDS, PhD, Thomas W. Evans Centennial Professor, University of Pennsylvania, Penn Dental Medicine – Microbiology, Philadelphia, PA

Wednesday, March 8, 2017; 12:00 noon

Dixon Lecture Hall, UNMC, College of Dentistry
40th & Holdrege (UNL East Campus)
Lincoln, NE

Presentation will be livestreamed to CON 2017 on the UNMC campus in Omaha

Hosted by: Dr. Tom Petro

Recent human microbiome analyses and animal model-based mechanistic studies collectively suggest that the pathogenesis of periodontitis is not mediated by a select few bacteria (traditionally known as ‘periopathogens’) but rather involves polymicrobial synergy and dysbiosis. The dysbiosis of the periodontal microbiota represents an alteration in the relative abundance or influence of individual members of the polymicrobial community (relative to their abundance or influence in health) leading to dysregulated host-microbial interactions that mediate destructive inflammation and bone loss. Functional specialization of community participants has given rise to several newly appreciated designations within the commensal-to-pathogen spectrum (e.g., accessory pathogens, keystone pathogens, and pathobionts). Although necessary, the bacteria are not sufficient to cause periodontitis, as it is the host inflammatory response to this polymicrobial challenge that predominantly inflicts damage to the periodontium. It is now well appreciated that the control of periodontal inflammation can indirectly exert antimicrobial effects. This is because periodontitis-associated bacteria thrive in an inflammatory environment. Indeed, the release into the gingival crevicular fluid of inflammatory breakdown products of connective tissue favors the outgrowth of certain species (e.g., proteolytic and asaccharolytic) that can benefit from these microenvironmental alterations.  Briefly stated, an initial inflammatory response (e.g., due to incipient dysbsiosis associated with poor oral hygiene) may select for those bacteria that can give rise to full-blown dysbiosis, thereby exacerbating inflammation and ultimately causing clinically evident periodontitis in susceptible individuals. Therefore, the control of inflammation should not only inhibit tissue damage but also suppress a nutritionally favorable environment that fuels dysbiosis.

All interested faculty, staff and students are invited to attend this presentation. The seminar will be recorded and available for those who cannot attend.

PCORI Announces new Application System for January 2017

In January, PCORI will launch a new funding application system, PCORI Online to enhance the application experience throughout the Letter of Intent and application submission process  The new PCORI Online will open to applicants on January 17, the first day that LOIs can be submitted for the Cycle 1 2017 funding opportunities.  All PCORI funding opportunities for Cycle 1 2017 onward will utilize the new system.

Three training sessions  will be offered to learn the details of how to use the new system, sessions will be:

  • 12:00 PM – 1:30 PM, January 12, 2017
  • 9:00 AM – 10:30 AM, January 18, 2017
  • 12:00 PM – 1:30 PM, January 24, 2017

Register Online

Writing Seminar for Post-Docs

Adrian Koesters, Ph.D., editorial grant specialist, will hold a six-session seminar for post-doctoral students on effective writing strategies beginning Jan. 10. The course, designed for post-doctoral researchers who wish to improve their basic writing skills, runs through Feb. 14. Participants must commit to attending at least five of the six sessions, which will be held Tuesdays from 1-1:50 p.m. at the Durham Research Center, Room 1005. Pre-registration is required. Registration is available via REDCap on the Post-Doc web page.