{"id":6299,"date":"2025-12-11T10:54:00","date_gmt":"2025-12-11T16:54:00","guid":{"rendered":"https:\/\/blog.unmc.edu\/infectious-disease\/?p=6299"},"modified":"2025-12-09T14:56:50","modified_gmt":"2025-12-09T20:56:50","slug":"unmc-id-transplant-infectious-diseases-research-group-leads-in-division-clinical-trials","status":"publish","type":"post","link":"https:\/\/blog.unmc.edu\/infectious-disease\/2025\/12\/11\/unmc-id-transplant-infectious-diseases-research-group-leads-in-division-clinical-trials\/","title":{"rendered":"UNMC ID Transplant\u00a0Infectious Diseases Research Group Leads in Division Clinical Trials"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\">\n<p><em>Content provided by Drs. Anum Abbas and Carlos Gomez<\/em><\/p>\n\n\n\n<p>Under the leadership of Dr. Anum Abbas\u00a0and Dr. Carlos A. Gomez, the <strong>UNMC ID Transplant Infectious Diseases Research Group\u00a0<\/strong>had an exceptionally productive year, bringing multiple industry-sponsored, NIH-funded, and investigator-initiated studies to UNMC. These efforts expand clinical trial access for immunocompromised patients, strengthen our division\u2019s research mission, and directly contribute to institutional research revenue and academic visibility.<\/p>\n\n\n\n<p><strong>Major Clinical Trials\/ Transplant ID \/UNMC 2025<\/strong><\/p>\n\n\n\n<p><strong>High-Enrollment \/ High-Impact Studies<\/strong><\/p>\n\n\n\n<p><em>NIH \u2013 COLT Trial (CTOT-44)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>CMV Vaccine in Orthotopic Liver Transplant Candidates (COLT)\u00a0\u2013 Pivotal NIH-funded randomized trial evaluating CMV vaccination in liver transplant candidates. \n<ul class=\"wp-block-list\">\n<li><span style=\"text-decoration: underline\">PI:\u00a0Sias Scherger<\/span> | Coordinator:\u00a0Mary Petersen. \u2192 UNMC ranks among the top enrolling sites nationally, and Dr. Scherger was invited to present the UNMC recruitment experience at the 2025 Investigator Meeting\u2014an exceptional recognition for an early-career investigator and a reflection of the strength of our TID research infrastructure.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><em>SymBio Pharmaceuticals \u2013 Brincidofovir Program (Adenovirus &amp; CMV)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>BCV-PA01 (Phase IIa)\u00a0\u2013 Multiple ascending-dose study of IV brincidofovir for adenovirus and CMV infection.\u00a0\n<ul class=\"wp-block-list\">\n<li><span style=\"text-decoration: underline\">PI:\u00a0Gomez, Sub-I: Scherger, Abbas<\/span> | Coordinator:\u00a0Matthew Palmer.\u00a0<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><em>AiCuris \u2013 Pritelivir Program<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>AIC316-03-II-01 (PRIOH-1)\u00a0\u2013 Randomized trial of pritelivir vs foscarnet for acyclovir-resistant HSV. \n<ul class=\"wp-block-list\">\n<li><span style=\"text-decoration: underline\">PI:\u00a0Abbas, Sub-Is: Gomez, Zimmer<\/span> | Coordinator:\u00a0Grace Rodriguez -&gt; (UNMC, Top 5 recruitment site worldwide)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><em>GSK RSV \u2013 Adjuvanted RSVPreF3 Vaccine Program<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>RSV OA-ADJ-031 (Phase 2b Extension)\u00a0\u2013 Safety and revaccination durability in adult lung &amp; kidney transplant recipients. \n<ul class=\"wp-block-list\">\n<li><span style=\"text-decoration: underline\">PI:\u00a0Abbas<\/span> | Coordinator:\u00a0Caitlin Harrison<br>\u2192 Strong enrollment positioning UNMC as a national leader in RSV vaccine studies in SOT.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><em>International RSV Consortium (ESCMID ESGREV)\u00a0\u2013 MD Anderson \/ UNMC<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><em>RSV Outcomes (2024-0389)<\/em> \u2013 Multicenter registry characterizing RSV in immunocompromised adults.\n<ul class=\"wp-block-list\">\n<li><span style=\"text-decoration: underline\">Local Leads:\u00a0Abbas, Gomez<\/span> | Coordinator:\u00a0Matthew Palmer. \u2192 Integrates UNMC into a premier international respiratory virus research group.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>Additional 2025 Studies Activated at UNMC<\/strong><\/p>\n\n\n\n<p><strong>Immunocompromised Host Observational &amp; Etiologic Studies<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><em>IC-SCARI (Strive, NIH network)\u00a0<\/em>\u2013 Global evaluation of severe acute respiratory infections in immunocompromised adults. \n<ul class=\"wp-block-list\">\n<li><span style=\"text-decoration: underline\">PI:\u00a0Gomez, Abbas<\/span> | Coordinator:\u00a0Mary Petersen<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><em>Karius mGENeSIS Registry<\/em>\u00a0\u2013 Prospective mNGS registry in solid organ transplant recipients.\n<ul class=\"wp-block-list\">\n<li><span style=\"text-decoration: underline\">Local Co-PI:\u00a0Gomez, Abbas<\/span> (Baylor, sponsor lead site)<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><em>Karius IMPACT<\/em> \u2013 Diagnostic mNGS pathway for cardiovascular infections.\n<ul class=\"wp-block-list\">\n<li><span style=\"text-decoration: underline\">Co-PI:\u00a0Gomez, Abbas<\/span>. (Baylor, sponsor lead site)<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>Advanced Diagnostic Trials in Transplant &amp; Oncology ID<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><em>Karius OPTIMUM (KAR-0025)<\/em>\u00a0\u2013 Randomized basket trial evaluating clinical utility of plasma mcfDNA sequencing in Oncology ID patients. \n<ul class=\"wp-block-list\">\n<li><span style=\"text-decoration: underline\">PI:\u00a0Gomez <\/span>| Sub-Investigators:\u00a0Abbas, Scherger, Zimmer, APPs: Knut, Tijerina, Schober| Coordinator:\u00a0Caitlin Harrison-&gt; first in class diagnostic study in ONC-ID outpatient setting.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p><strong>Vaccine Trials<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><em>Pfizer C. difficile Vaccine (C4771002<\/em>)\u00a0\u2013 Phase III placebo-controlled RCT in adults \u226565.\n<ul class=\"wp-block-list\">\n<li><span style=\"text-decoration: underline\">PI:\u00a0Gomez<\/span> | Sub-Investigators: Brett Major, Abbas. Coordinator:\u00a0Neja Menyweather<br>\u2192 High-visibility national vaccine program added to the TID\/ID portfolio.<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n\n\n\n<p>We are very proud of the Transplant ID Research Group for a very active year with multiple new industry-sponsored, NIH-funded, and international studies launched at UNMC, including several high-enrolling trials and upcoming pivotal projects. These efforts involve a large portion of our research team and reflect our mission to expand clinical trial access and improve care for immunocompromised patients. Our coordinators and collaborating teams put in tremendous work, and we want to recognize these efforts and thank our team for their partnership in our shared goal.<\/p>\n\n\n\n<form name=\"s2form\" method=\"post\" action=\"https:\/\/blog.unmc.edu\/infectious-disease\/subscribe2\/\"><input type=\"hidden\" name=\"ip\" value=\"216.73.216.113\" \/><span style=\"display:none !important\"><label for=\"firstname\">Leave This Blank:<\/label><input type=\"text\" id=\"firstname\" name=\"firstname\" \/><label for=\"lastname\">Leave This Blank Too:<\/label><input type=\"text\" id=\"lastname\" name=\"lastname\" \/><label for=\"uri\">Do Not Change This:<\/label><input type=\"text\" id=\"uri\" name=\"uri\" value=\"http:\/\/\" \/><\/span><p><label for=\"s2email\">Your email:<\/label><br><input type=\"email\" name=\"email\" id=\"s2email\" value=\"Enter email address...\" size=\"20\" onfocus=\"if (this.value === 'Enter email address...') {this.value = '';}\" onblur=\"if (this.value === '') {this.value = 'Enter email address...';}\" \/><\/p><p><input type=\"submit\" name=\"subscribe\" value=\"Subscribe\" \/>&nbsp;<input type=\"submit\" name=\"unsubscribe\" value=\"Unsubscribe\" \/><\/p><\/form>\r\n\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Under the leadership of Dr. Anum Abbas\u00a0and Dr. Carlos A. Gomez, the UNMC ID Transplant Infectious Diseases Research Group\u00a0had an exceptionally productive year, bringing multiple industry-sponsored, NIH-funded, and investigator-initiated studies to UNMC.<\/p>\n","protected":false},"author":562,"featured_media":6320,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_s2mail":"","footnotes":""},"categories":[202,4,16,112,45],"tags":[20,198,3],"class_list":["post-6299","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bench-to-bedside","category-faculty-and-staff","category-research","category-transplant-id","category-unmc-id-achievements","tag-researchid","tag-transplantid","tag-unmcid"],"_links":{"self":[{"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/posts\/6299","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/users\/562"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/comments?post=6299"}],"version-history":[{"count":2,"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/posts\/6299\/revisions"}],"predecessor-version":[{"id":6302,"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/posts\/6299\/revisions\/6302"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/media\/6320"}],"wp:attachment":[{"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/media?parent=6299"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/categories?post=6299"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/tags?post=6299"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}