{"id":314,"date":"2017-08-18T08:00:24","date_gmt":"2017-08-18T13:00:24","guid":{"rendered":"https:\/\/blog.unmc.edu\/infectious-disease\/?p=314"},"modified":"2017-08-18T10:12:54","modified_gmt":"2017-08-18T15:12:54","slug":"cephalexin-with-or-without-tmp-smx-showed-similar-clinical-cure-rates-for-uncomplicated-cellulitis","status":"publish","type":"post","link":"https:\/\/blog.unmc.edu\/infectious-disease\/2017\/08\/18\/cephalexin-with-or-without-tmp-smx-showed-similar-clinical-cure-rates-for-uncomplicated-cellulitis\/","title":{"rendered":"Cephalexin with or without TMP-SMX Showed Similar Clinical Cure Rates for Uncomplicated Cellulitis"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\"><p><em>Content courtesy of Philip Chung, PharmD, MS, BCPS<\/em><\/p>\n<p>The Infectious Diseases Society of America recommends use of antimicrobial agent active only against streptococci (e.g., cephalexin) for management of cellulitis in patients without systemic signs of infection, penetrating trauma, evidence of MRSA, and injection drug use. \u00a0Despite this recommendation, healthcare providers frequently prescribe additional antimicrobial agents with anti-MRSA activity (e.g., cephalexin plus trimethoprim-sulfamethoxazole).<\/p>\n<p>A recent multicenter, double-blind, randomized, controlled trial evaluated the efficacy of cephalexin alone or in combination with trimethoprim-sulfamethoxazole (TMP-SMX) for treatment of acute uncomplicated cellulitis in the outpatient setting. \u00a0Clinical cure rates were similar between the combination therapy arm (83.5%) and the monotherapy arm (85.5%). \u00a0Adverse event rates and secondary outcomes (including overnight hospitalization, recurrent skin infections, and similar infection in household contacts) were not different between treatment arms.<\/p>\n<p>For additional details, please read\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28535235\">Moran GJ,\u00a0<em>et al<\/em>. JAMA 2017;317(20):2088-96.<\/a><\/p>\n<form name=\"s2form\" method=\"post\" action=\"https:\/\/blog.unmc.edu\/infectious-disease\/subscribe2\/\"><input type=\"hidden\" name=\"ip\" value=\"216.73.216.131\" \/><span style=\"display:none !important\"><label for=\"firstname\">Leave This Blank:<\/label><input type=\"text\" id=\"firstname\" name=\"firstname\" \/><label for=\"lastname\">Leave This Blank Too:<\/label><input type=\"text\" id=\"lastname\" name=\"lastname\" \/><label for=\"uri\">Do Not Change This:<\/label><input type=\"text\" id=\"uri\" name=\"uri\" value=\"http:\/\/\" \/><\/span><p><label for=\"s2email\">Your email:<\/label><br><input type=\"email\" name=\"email\" id=\"s2email\" value=\"Enter email address...\" size=\"20\" onfocus=\"if (this.value === 'Enter email address...') {this.value = '';}\" onblur=\"if (this.value === '') {this.value = 'Enter email address...';}\" \/><\/p><p><input type=\"submit\" name=\"subscribe\" value=\"Subscribe\" \/>&nbsp;<input type=\"submit\" name=\"unsubscribe\" value=\"Unsubscribe\" \/><\/p><\/form>\r\n\n<div style=\"display: none;\"><a rel=\"nofollow\" href=\"\/voicedwhispering.php\" title=\"NMlgs    khg dJ ecFERw\">NMlgs    khg dJ ecFERw<\/a><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Content courtesy of Philip Chung, PharmD, MS, BCPS The Infectious Diseases Society of America recommends use of antimicrobial agent active only against streptococci (e.g., cephalexin) for management of cellulitis in patients without systemic signs of infection, penetrating trauma, evidence of MRSA, and injection drug use. \u00a0Despite this recommendation, healthcare providers frequently prescribe additional antimicrobial agents [&hellip;]<\/p>\n","protected":false},"author":532,"featured_media":315,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_s2mail":"yes","footnotes":""},"categories":[27],"tags":[],"class_list":["post-314","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nebraska-asap"],"_links":{"self":[{"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/posts\/314","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/users\/532"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/comments?post=314"}],"version-history":[{"count":3,"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/posts\/314\/revisions"}],"predecessor-version":[{"id":362,"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/posts\/314\/revisions\/362"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/media\/315"}],"wp:attachment":[{"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/media?parent=314"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/categories?post=314"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/tags?post=314"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}