{"id":2443,"date":"2019-04-04T08:25:34","date_gmt":"2019-04-04T13:25:34","guid":{"rendered":"https:\/\/blog.unmc.edu\/infectious-disease\/?p=2443"},"modified":"2019-03-13T13:31:58","modified_gmt":"2019-03-13T18:31:58","slug":"md-phd-brings-together-clinical-and-basic-science-research","status":"publish","type":"post","link":"https:\/\/blog.unmc.edu\/infectious-disease\/2019\/04\/04\/md-phd-brings-together-clinical-and-basic-science-research\/","title":{"rendered":"MD\/PhD brings clinical and basic science research together"},"content":{"rendered":"<div class=\"panel body-content\"><div class=\"panel__container\"><p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-2445 alignleft\" src=\"https:\/\/blog.unmc.edu\/infectious-disease\/wp-content\/uploads\/sites\/54\/2019\/03\/IMG_1496-243x300.jpeg\" alt=\"\" width=\"243\" height=\"300\" srcset=\"https:\/\/blog.unmc.edu\/infectious-disease\/wp-content\/uploads\/sites\/54\/2019\/03\/IMG_1496-243x300.jpeg 243w, https:\/\/blog.unmc.edu\/infectious-disease\/wp-content\/uploads\/sites\/54\/2019\/03\/IMG_1496-1243x1536.jpeg 1243w, https:\/\/blog.unmc.edu\/infectious-disease\/wp-content\/uploads\/sites\/54\/2019\/03\/IMG_1496-1658x2048.jpeg 1658w, https:\/\/blog.unmc.edu\/infectious-disease\/wp-content\/uploads\/sites\/54\/2019\/03\/IMG_1496-768x949.jpeg 768w, https:\/\/blog.unmc.edu\/infectious-disease\/wp-content\/uploads\/sites\/54\/2019\/03\/IMG_1496-829x1024.jpeg 829w, https:\/\/blog.unmc.edu\/infectious-disease\/wp-content\/uploads\/sites\/54\/2019\/03\/IMG_1496-120x148.jpeg 120w\" sizes=\"auto, (max-width: 243px) 100vw, 243px\" \/><\/p>\n<p>Kelsey Yamada is an MD\/PhD student in Dr.\u00a0Tammy Kielian&#8217;s laboratory studying Staphylococcus aureus.\u00a0 We enjoyed learning more about him and his work!<\/p>\n<p><strong>Tell us a little about yourself.<\/strong><\/p>\n<p><em>I am originally from Hawaii, but moved to Nebraska over a decade ago to attend Creighton University. After graduating with my B.S. Chemistry I moved to Bethesda, MD to work at the NIH. This gave me the opportunity to work along side of physician-scientists who were at the top of their fields, and ultimately helped me to decide on a career in translational medical research. My wife and I loved our time in Omaha, which led me back to Omaha and UNMCs M.D.\/Ph.D. program. While I am not sure what medical field I will ultimately choose, I am certain that I am interested in studying host-pathogen interactions during chronic disease.\u00a0<\/em><\/p>\n<p><strong>What are you studying for your thesis, and how do you think your work will inform your future practice of medicine?<\/strong><\/p>\n<p><em><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-1858\" src=\"https:\/\/blog.unmc.edu\/infectious-disease\/wp-content\/uploads\/sites\/54\/2018\/07\/bacteria-808158__340-300x214.jpg\" alt=\"\" width=\"259\" height=\"185\" srcset=\"https:\/\/blog.unmc.edu\/infectious-disease\/wp-content\/uploads\/sites\/54\/2018\/07\/bacteria-808158__340-300x214.jpg 300w, https:\/\/blog.unmc.edu\/infectious-disease\/wp-content\/uploads\/sites\/54\/2018\/07\/bacteria-808158__340-120x86.jpg 120w, https:\/\/blog.unmc.edu\/infectious-disease\/wp-content\/uploads\/sites\/54\/2018\/07\/bacteria-808158__340.jpg 476w\" sizes=\"auto, (max-width: 259px) 100vw, 259px\" \/>My thesis research focused on trying to understand how orthopedic implant associated\u00a0S. aureus\u00a0biofilms modulates the metabolism of monocytes in order to promote the establishment and persistence of infection.\u00a0 Though my current research is on a fairly specific ailment, it may not directly inform my clinical practice in the future (unless of course I go into orthopedics). However, I have had a lot of opportunities to work on both the clinical and basic science side of a clinical study on orthopedic implant infections. It has helped me to understand how important communication is when trying to develop and carry out a clinical study. In my future, it will be essential for me to bridge the gap between the clinical and research teams.\u00a0<\/em><\/p>\n<p><strong>Tell us something about yourself unrelated to medicine.<\/strong><\/p>\n<p><em>I\u2019ve watched the office from episode 1, an embarrassing number of times. But I always skip over the episodes with Will Ferrell. My friends and I demolish trivia night, unless it has to do with Deangelo Vickers and his juggling.\u00a0<\/em><\/p>\n<p>&nbsp;<\/p>\n<p><strong>We&#8217;re always excited to learn about our students&#8217; research that helps us understand problems we see all the time in clinic.\u00a0 If you&#8217;re interested in learning more about Kelsey&#8217;s work, check out his publications below:<\/strong><\/p>\n<p><strong>Yamada, K.J.,<\/strong> Barker, T., Dyer, K.D., Rice, T.A., Percopo, C.M., Garcia-Crespo, K.E., Cho, S., Lee, J.J., Druey, K.M., Rosenberg, H.F. Eosinophil-associated Ribonuclease 11 is a Macrophage Chemoattractant.\u00a0<em>J. Biol. Chem.<\/em>, 290:8863-8875, 2015. PMID: 25713137<\/p>\n<p><strong>Yamada, K.J.,<\/strong> Heim, C.E., Aldrich, A.L., Gries, C.M., Staudacher, A.G., Kielian, T. Arginase-1 Expression in Myeloid Cells Regulates\u00a0<em>Staphylococcus aureus<\/em>\u00a0Planktonic but Not Biofilm Infection.\u00a0<em>Infect Immun<\/em>. 86:e206-218, 2018. PMID: 29661929<\/p>\n<p><strong>Yamada, K.J.,<\/strong> Kielian, T. Biofilm-Leukocyte Cross-Talk: Impact on Immune Polarization and Immunometabolism.\u00a0<em>J. Innate Immun<\/em>., 2018. PMID: 30347401<\/p>\n<p>Zhou, C., Bhinderwala, F., Lehman, M.K., Thomas, V.C., Chaudhari, S.S.,<strong>\u00a0Yamada, K.J.<\/strong>, Powers, R., Kielian, T., Fey, P.D. Urease is an essential component of the acid response network of\u00a0<em>Staphylococcus aureus<\/em>\u00a0and is required for a persistent murine kidney infection.\u00a0<em>PLoS Pathog<\/em>., 2018. PMID: 30608981<\/p>\n<p><strong>Yamada, K.J.<\/strong>, Xi, X., Attri, K.S., Zhang, W., Singh, P.K., Bronich, T.K., Kielian, T. Nanoparticle targeting of monocyte metabolism to treat Staphylococcus aureus prosthetic joint infection. (In revision at\u00a0<em>Journal of immunology<\/em>).<\/p>\n<p>Lehman, M.K., Nuxoll, A.S.,\u00a0<strong>Yamada, K.J.<\/strong>, Kielian, T., Carson, S.D., Fey, P.D. Protease-mediated growth of Staphylococcus aureus on host proteins is opp3-dependent. (In submission to\u00a0<em>mBio<\/em>).<\/p>\n<form name=\"s2form\" method=\"post\" action=\"https:\/\/blog.unmc.edu\/infectious-disease\/subscribe2\/\"><input type=\"hidden\" name=\"ip\" value=\"216.73.216.172\" \/><span style=\"display:none !important\"><label for=\"firstname\">Leave This Blank:<\/label><input type=\"text\" id=\"firstname\" name=\"firstname\" \/><label for=\"lastname\">Leave This Blank Too:<\/label><input type=\"text\" id=\"lastname\" name=\"lastname\" \/><label for=\"uri\">Do Not Change This:<\/label><input type=\"text\" id=\"uri\" name=\"uri\" value=\"http:\/\/\" \/><\/span><p><label for=\"s2email\">Your email:<\/label><br><input type=\"email\" name=\"email\" id=\"s2email\" value=\"Enter email address...\" size=\"20\" onfocus=\"if (this.value === 'Enter email address...') {this.value = '';}\" onblur=\"if (this.value === '') {this.value = 'Enter email address...';}\" \/><\/p><p><input type=\"submit\" name=\"subscribe\" value=\"Subscribe\" \/>&nbsp;<input type=\"submit\" name=\"unsubscribe\" value=\"Unsubscribe\" \/><\/p><\/form>\r\n\n<\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Kelsey Yamada is an MD\/PhD student in Dr.\u00a0Tammy Kielian&#8217;s laboratory studying Staphylococcus aureus.\u00a0 We enjoyed learning more about him and his work! Tell us a little about yourself. I am originally from Hawaii, but moved to Nebraska over a decade ago to attend Creighton University. After graduating with my B.S. Chemistry I moved to Bethesda, [&hellip;]<\/p>\n","protected":false},"author":629,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_s2mail":"yes","footnotes":""},"categories":[34,16],"tags":[],"class_list":["post-2443","post","type-post","status-publish","format-standard","hentry","category-medical-education","category-research"],"_links":{"self":[{"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/posts\/2443","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/users\/629"}],"replies":[{"embeddable":true,"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/comments?post=2443"}],"version-history":[{"count":10,"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/posts\/2443\/revisions"}],"predecessor-version":[{"id":2491,"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/posts\/2443\/revisions\/2491"}],"wp:attachment":[{"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/media?parent=2443"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/categories?post=2443"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blog.unmc.edu\/infectious-disease\/wp-json\/wp\/v2\/tags?post=2443"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}