Research Funding

ACGT 2014 Young Investigators Award RFA

ALLIANCE FOR CANCER GENE THERAPY, INC. (“ACGT”)

REQUEST FOR APPLICATIONS

2014 YOUNG INVESTIGATOR AWARD Posted: August 27, 2014

Abstract Deadline: September 16, 2014 at 4pm E.S.T. Invitation to Submit Application: October 2, 2014

Deadline for Completed Application: October 30, 2014 at 4 pm E.S.T.

PROGRAM GUIDELINES:

PURPOSE

Alliance for Cancer Gene Therapy, Inc. (ACGT) funds research aimed at furthering the development of cell and gene therapy approaches to the treatment of cancer. To this end, ACGT offers its Young Investigator Award to qualified scientists at the Tenure Track Assistant Professor level.

ELIGIBILITY REQUIREMENTS

Candidates for a Young Investigator Award must hold an MD, MPH, PhD, or equivalent degree, and be a TENURE TRACK Assistant Professor within FIVE YEARS of their initial appointment to this rank at the time of award activation. (January 2015). The investigator must be conducting ORIGINAL research as an INDEPENDENT faculty member reporting DIRECTLY to the Department Chair or Division Chief, with DEDICATED laboratory space allocated by the Department Chair. ACGT has no citizenship restrictions, and research supported by the award must be conducted at medical schools and research centers located in the United States (including Puerto Rico) or Canada.

ACGT will accept a maximum of one resubmission of an application. Please indicate date of submitted application. Note: LOIs are not considered applications. Applicants who fail to receive funding after two submissions may resubmit but only if the application is fundamentally revised to qualify as new. A new application is expected to be substantially different in content and scope with more significant differences than are normally encountered in an amended application.

FINANCIAL INFORMATION

The award for The Young Investigator Award provides up to a maximum of $250,000 distributed up to 2-3 years, inclusive of a maximum of 10% indirect costs. The funds may be used at the recipient’s discretion for salary, technical assistance, supplies, animals or capital equipment, but may not support staff not directly related to the project, e.g. secretaries or administrative assistants. Purchase of equipment is not allowed in the final year of the grant. Continued support is contingent upon submission and approval of a non- competitive renewal application each year.

ACGT RESEARCH OBJECTIVES

The overall objectives of this grant are to advance cell and gene therapy into the causes, treatment and prevention of all types of cancer by promoting development of novel and innovative studies by young investigators. The emphasis of this initiative is to promote basic and pre-clinical research approaches utilizing cells and genes as medicine. ACGT will direct its grants into areas of cell and gene therapy research that have demonstrated great promise. The seven main areas of research ACGT will support are:

1. Tumor-Specific Replicating Viruses and Bacteria

2. Anti-angiogenesis

3. Immune-modulatory Therapy and Cancer Vaccines

4. Oncogene/Suppressor Oncogene/Apoptosis Directed Therapy

5. Tumor Targeting and Vector Development

6. Cancer Stem Cell Directed Therapy

7. Other Gene/Cell based Therapies

2014 ACGT YOUNG INVESTIGATOR AWARD

APPLICATION PROCEDURES

There is a two-step process for submitting applications. A candidate must submit the following by the required deadlines:

 Step 1: A pre-application (called Letter of Intent [LOI] on Proposal Central site) that includes an abstract of the proposed research and an updated biographical sketch. The LOI/abstracts will then be reviewed by the Scientific Council and selected ones will be invited to submit full applications

 Step II: For those invited to submit, a completed electronic application, including templates and a Signed Administrative and Signature Page(s) scanned and attached to the front of the completed application template

NOTE: A paper copy submission is NOT required.

INSTRUCTIONS

Instructions for completing the application are available at the ACGT website under Research Grants at www.acgtfoundation.org and also through the proposalCENTRAL website https://proposalcentral.altum.com/Login.asp.

CUSTOMER SUPPORT

If you have any questions regarding the online application, please contact proposalCENTRAL Customer

Support by e-mail at pcsupport@altum.com

Telephone: 1-800-875-2562 x 227 (toll-free) or (301) 916-4557 x 227.

INSTITUTIONAL POLICY

Grant funds will be disbursed following execution of a grant agreement between the grantee institution and ACGT. The following items will be covered in ACGT grant agreements with grantee institutions:

 ACGT shall receive a reasonable royalty return, including license fees on inventions and improvements made by investigators on research supported by its grants.

 Overhead of up to 10% is included in the awarded amount. The 2014 YOUNG INVESTIGATOR Award will support research projects up to 2-3 years with annual non-

competitive renewal applications.

 Grantees and their affiliated institutions are required to submit periodic progress reports to

ACGT. In addition, they are expected to share their research findings with the scientific community in a timely fashion through presentation at professional meetings and

publication in scientific journals.

 ACGT will request acknowledgment of the grant in any presentations and/or publications by the investigators and/or institutions.

 The grantee institution will agree (i) to indemnify ACGT solely with respect to claims relating to the award of a grant and (ii) that all research supported by ACGT will be conducted in

accordance with all applicable state and Federal laws, rules and regulations.

 Awards to an institution will terminate when the principal investigator departs from the grantee institution, and can be re-initiated at an alternate institution subject to ACGT

RESPONSIBILITY OF THE GRANTEE INSTITUTION

An application for a grant must bear the signature of the official authorized to sign for the institution, acknowledging the above policies.

PROGRAM INQUIRIES

For application information, policy and procedures, and general information, please visit ACGT’s

Website at www.acgtfoundation.org.

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